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Understanding the cancer-predisposing syndrome caused by defective proofreading activity of POLE and POLD1

Germline missense pathogenic variants in the exonuclease domains (ED) of polymerases epsilon (POLE) and delta (POLD1), which affect the proofreading capabilities of these polymerases, predispose to multiple colorectal adenomas and carcinomas, causing the so-called polymerase proofreading-associated polyposis (PPAP). Read More

Profile PhotoareteidibellMay 25, 2020

Inflammation and other cell-cell responses to microenvironmental nutrient shortage

Targeting signals elicited by metabolic stress may help the immune system target malignant cells, and that metabolites regulate the communication between immune and tumor cells also through modulation of peptidic signals like IL-8 and IL-6.Read More

Profile PhotoareteidibellMay 21, 2020

Digital therapeutics for overburdened healthcare systems

While the term digital therapeutic may sound futuristic, these therapies are already a reality. As this new category of medicine continues to be integrated across healthcare ecosystems, digital therapeutics will increasingly influence the way healthcare is delivered and consumed across the world.Read More

Profile PhotoareteidibellMarch 30, 2020

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